For future studies, pharmaceutical polymers with higher aqueous solubility should be investigated in order to thoroughly examine the potential of utilizing the immediate release property of Upsalite. DSC measurements on the loaded material suggested that the drug was partially crystallized after incorporation, meanwhile the XRD diffractogram implied that the drug was in a state lacking long range order. It has an excellent absorption capacity and can take up both oil and water simultaneously. Cinnarizine, a BCS class II drug, was loaded into the pores of the mesoporous material via a soaking method, corresponding to a drug loading of 8.68 wt%. © 2020 - Pharma Excipients. RESULTS: Mesoporous magnesium carbonate has a high surface area and pore volume. Explore The Science Behind The biocompatibility of the formed magnesium carbonate material was evaluated in terms of Pharma-MMC, Pharmaceutical grade Mesoporous Magnesium Carbonate, Pharma-MMC is a proprietary drug delivery technology for amorphous stabilization and solubility enhancement of drug substances, Excipient cGMP Certification Organisations, Learn more about Pharma-MMC and Disruptive Materials, Pharmaceutical Excipients – Some Definition, Inactive ingredient search for approved drug products in the USA, Quality by Design for ANDAs: An Example for Immediate-Release Dosage Forms, Long term amorphous stability of poorly soluble drugs (>12 months). The drug loaded material was combined with two pharmaceutical polymers, Aquasolve LG and Klucel ELF, and extruded into filaments with a single screw extruder. It provides instant and long-lasting mattifying effect when applied on human skin without drying or irritating skin and exhibits no measured flash-back effect. Mesoporous Magnesium Carbonate for Pharmaceuticals, Cosmetics and Sports. In this thesis, the incorporation of drug loaded mesoporous magnesium carbonate as an excipient for the additive manufacturing of oral tablets by fused deposition modeling was investigated. © 2020 - Pharma Excipients. DSC measurements on the loaded material … Pharma-MMC, Pharmaceutical grade Mesoporous Magnesium Carbonate Pharma-MMC is a proprietary drug delivery technology for amorphous stabilization and solubility enhancement of drug substances and for unique drug formulations – addressing unmet industry needs: Additive manufacturing, 3D-printing, Fused deposition modeling (FDM), Fused filament fabrication (FFF), Drug delivery, Amorphous drugs, Mesoporous magnesium carbonate, Upsalite, Cinnarizine, Hydroxypropyl cellulose (HPC), Hydroxypropyl methylcellulose acetate succinate (HPMCAS), Klucel ELF, AquaSolve LG, More Information about Mesoporous magnesium carbonate, Spray drying of naproxen and naproxen sodium for improved tableting and dissolution…, Hopper design for piezo-actuated granular flow in powder bed 3D food printing, Chitosan as a machine for biomolecule delivery: A review, Self-Nanoemulsifying System Loaded with Sildenafil Citrate and Incorporated within…, Novel Coating Uniformity Models for Tablet Pan Coaters, Empty mesoporous silica particles significantly delay disease progression and extend survival in a mouse model of ALS, Transdermal Delivery of Salmon Calcitonin Using a Dissolving Microneedle Array: Characterization, Stability, and In vivo Pharmacodynamics, An innovative sampling interface for monitoring flowing pharmaceutical powder mixtures. Pharma-MMC has a porous structure with a narrow pore size distribution and an extraordinary high surface area. Upsalite ®, a mesoporous magnesium carbonate Stay ahead of the curve with ingredient branding and value-added services - meet Upsalite, a patented porous material with numerous opportunities in cosmetics and sports. Abdelki, Andreas, Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Materials Science and Engineering, Nanotechnology and Functional Materials. or continue here: Fused deposition modeling of API-loaded mesoporous magnesium carbonate Download the thesis here: Fused deposition modeling of API-loaded mesoporous magnesium carbonate. In this thesis, the incorporation of drug loaded mesoporous magnesium carbonate as an excipient for the additive manufacturing of oral tablets by fused deposition modeling was investigated. In 2012, researchers from the Division of Nanotechnology and Functional Materials at Uppsala University in Sweden created Upsalite®, a form of mesoporous magnesium carbonate (MMC) that until then, had been impossible to create.

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